A major research on the H7N9 avian flu released on the 25th April on the official website of the world-renowned medical journal “The Lancet”. This research paper has been completed by a team of Chinese scientists and the paper for the first time in the international warned that the H7N9 virus is becoming more suitable for mammals infection, which makes the virus more susceptible to human beings.
At the same time, the results of this study for the first time announced the complete sequence of genes of one case of human infection and one case of bird infection. And it is the world’s first report showing that cytokine storm similar that happen in the SARS virus in the severe H7N9 infection.
“This is the first time we have obtained evidence of the spread of the H7N9 virus from birds to humans via experiments, rather than speculation.” the team leader, the National Health and Family Planning Commission, expert of H7N9 avian flu prevention and control work Li Lanjuan said.
Moreover, the research team found in the study of the viral genome that H7 virus gene mutated amino acid sites, which makes the virus more easily to transmit from birds to human cells. “If the 627 and 701 amino acid sites of the PB2 gene mutation happen at the same time, it will result in efficient human-to-human transmission.” the paper made such statements. The research team has found a variation at the 701 point.